Screen crystallization solvents for H2O, as a small amount of H2O in solvents or reagents can affect not only the formation of hydrates but also polymorph formation. For an example of how small amounts of water in a starting material affected polymorph formation, see Gross, T. D.; Schaab, K.; Ouellette, M.; Zook, S.; Reddy, J. P.; Shurtleff, A.; Sacaan, A. I.; Alebic-Kolbah, T.; Bozigian, H. Org. Process Res. Dev. 2007, 11, 365.
-
About
-
NEAL G. ANDERSON, Ph.D.
ANDERSON'S PROCESS SOLUTIONSMcMinnville, Oregon 97128
(541)778-0516
-
- SCHEDULE A SHORT COURSE IN-HOUSE
Customize For Your Company
In-house short courses allow researchers to identify and focus on skills and challenges unique to your company. In-house courses also provide a considerable savings in both registration fees and time away from the work site.
More Information on SHORT COURSES HERE
-
PROCESS TIPS
- Could NDMA be present in process water?
- Smelly Impurities
- Metathesis catalysts and reducing olefin isomerization
- Removing Ru from metathesis reactions
- Benzene as contaminant
- Removing Metal Ions from Reactors
- Recent review on statistical DoE
- How Much? 2-Ethylhexanoic Acid Limits
- Quenching carbodiimides
- Highlighting Continuous Flow Chemistry
- Controlling Residual Arylboronic Acids as Potential Genotoxic Impurities in APIs
- Recent Process Validation Guidance and Process Implementation
- A Perspective on Biocatalysis
- Roles of Water in Metal-Catalyzed Cross-Couplings
- Functional Group Conversions by Biocatalysts
- Expanding Potential for Biocatalysis
- Addition Sequence for Solvents and Solids Can Be Important
- Is a Catalyst Really Necessary?
- Screen Crystallization Solvents with H2O Present
- Designing Routes and Selecting Reagents
- NAVIGATION
- Bookmarks
- Tags