PUBLICATIONS

Anderson, N. G., Practical Process Research & Development – A Guide for Organic Chemists; 2^nd edition; Academic Press: San Diego; 2012.  (ISBN: 9780123865373: see http://store.elsevier.com/product.jsp?isbn=9780123865373&_requestid=113257).

Anderson, N. G., Practical Process Research & Development; Academic Press: San Diego; 2000.  (ISBN 0-12-059475-7; see http://www.elsevierdirect.com/ISBN/9780120594757/Practical-Process-Research-and-Development).

Anderson, N. G.; Nelson, T. D. “API Cost of Goods: Discovery to Early Development,” Chapter 4 in Early Drug Development – Bringing a Preclinical Candidate to the Clinics; Giordanetto, F., Ed.; Methods and Principles in Medicinal Chemistry Series – VCH Wiley; 2018; pp 49 – 72.

Weissman, S. A.;Anderson, N. G. “Design of Experiments (DoE) and Process Optimization. A Review of Recent Publications,” Org. Process Res. Dev. 2015, 19, 1605.

Anderson, N. G. “Using Continuous Processes to Increase Production.” Org. Process Res. Dev. 2012, 16, 852.

Anderson, N. G.; Burdick, D. C.; Reeve, M. M. “Current Practices of Process Validation for Drug Substances and Intermediates.” Org. Process Res. Dev. 2011, 15, 162.

Haney, B. P.; Mason, P.; Anderson, N. G. “Response to the Comments by Bercu and Callis on our Communication ‘Controlling the Genotoxins Ethyl Chloride and Methyl Chloride Formed During the Preparation of Amine Hydrochloride Salts from Solutions of Ethanol and Methanol’.” Org. Process Res. Dev. 2009, 13, 921.

Haney, B. P.; Mason, P.; Anderson, N. G. “Response to the Comments by Bercu and Callis on our Communication ‘Controlling the Genotoxins Ethyl Chloride and Methyl Chloride Formed During the Preparation of Amine Hydrochloride Salts from Solutions of Ethanol and Methanol’.” Org. Process Res. Dev. 2009, 13, 921.

Anderson, N. G. “The Impact of Process Chemists and Engineers on Green Chemistry.” Org. Process Res. Dev. 2008, 12, 1019.

Anderson, N. G. “Process Research: How Much?  How Soon?” Chapter 2 in The Art of Drug Synthesis; Johnson, D. S.; Li, J. J., Eds.; Wiley: New York; 2007; pp 11-28.

Anderson, N. G. “Developing Processes for Crystallization-Induced Asymmetric Transformation.” Org. Process Res. Dev. 2005, 9, 800.

Anderson, N. G. “Assessing the Benefits of Direct Isolation Processes.” Org. Process Res. Dev. 2004, 8, 260.

Anderson, N. G. “Practical Use of Continuous Processing in Developing and Scaling Up Laboratory Processes.” Org. Process Res. Dev. 2001, 5, 613.

Rosso, V. W.; Lust, D. A.; Bernot, P. J.; Grosso, J. A.; Modi, S. P.; Rusowicz, A.; Sedergran, T. C.; Simpson, J. H.; Srivastava, S. K.; Humora, M. J.; Anderson, N. G. “Removal of Palladium from Organic Reactions by Trimercaptotriazine.” Org. Process Res. Dev. 1997, 1, 311.

Anderson, N. G.; Coradetti, M. L.; Cronin, J. A.; Davies, M. L.; Gardineer, M. B.; Kotnis, A. S.; Lust, D. A.; Palaniswamy, V. A. “Generation and Fate of Regioisomeric Sidechain Impurities in the Preparation of Fosinopril Sodium.” Org. Process Res. Dev. 1997, 1, 315.

Anderson, N. G.; Ary, T. D.; Berg, J. A., et al. “Process Development of 5-Fluoro-3-[3-[4-(5-methoxy-4-pyrimidinyl)-1-piperazinyl]propyl]-1H-indole Dihydrochloride.” Org. Process Res. Dev. 1997, 1, 300.

Anderson, N. G.; Ciaramella, B. M.; Feldman, A. F.; Lust, D. A.; Moniot, J. L.; Moran, L.; Polomski, R. E.; Wang, S. S. Y. “Process Development for the Preparation of a Monopril Intermediate by a Trimethylsilyl-Modified Arbuzov Reaction.” Org. Process Res. Dev. 1997, 1, 211.

Anderson, N. G.; Lust, D. A.; Colapret, K. A.; Simpson, J. H.; Malley, M. F.; Gougoutas, J. Z. “Sulfonation with Inversion by Mitsunobu Reaction: An Improvement on the Original Conditions.” J. Org. Chem. 1996, 61, 7955.

Anderson, N. G.; Carson, J. R. “Synthesis and Biological Activity of 5-(4-Chlorobenzoyl)-4-(hydroxy-methyl)-1-methyl-1-H-pyrrole-2-acetic Acid, a Major Metabolite of Zomepirac Sodium.” J. Med. Chem. 1980, 23, 98.

Anderson, N. G.; Lawton, R. G. “Intramolecular Photochemical Closure to 4-Tryptophan-substituted Tiglate Derivatives.” Tetrahedron Lett. 1977, 22, 1843.

PRESENTATIONS

“Route Selection” and “Reagent & Solvent Selection,” invited lectures at the 2^nd International School of Process Chemistry, Gargnano Italy, April 8 – 11, 2018.

“Looking Ahead from Academia to Pharma: The Importance of Interdisciplinary Thinking,” invited seminars presented at The University of Manchester, 4 December 2015, and at the University of Victoria, 26 March 2015.

“Continuous Reactions and Beyond,” invited lecture at the AMRI Chemical Development Symposium, Albany NY, October 3, 2013.

“Some Current R&D Challenges in the Pharmaceutical Industry,” keynote lecture, Northwest Regional Meeting, American Chemical Society, Corvallis, Oregon, July 22, 2013.

“Ask the Experts: The uses, challenges and benefits of flow chemistry to optimize drug development” Future Medicinal Chemistry September 2012, 4(14), 1779 (doi:10.4155/fmc.12.106).

Lectures on process chemistry at the University of Oregon, summer 2012and summer 2013.

“Controlling Genotoxic Impurities in APIs,” invited lecture at the Fourth Drug Innovation and Technology Seminars, Shanghai, China, December 9, 2011.

“Case Studies on the Development of Two Drugs, the 1980s and Today,” invited lecture at the University of Wisconsin at Madison, October 5, 2011.

“Development of APIs — Efficiencies for a New Decade,” Pre-Conference Workshop presented at Cambridge HealthTech Institute’s Symposium on Process Chemistry, Philadelphia PA, June 1, 2011.

“Process Validation from the Standpoint of an Organic Chemist, or Examples of What Can Go Wrong When Implementing Processes On-Scale,” lecture recorded for Lehigh University’s Chemistry Department, June 30, 2010.

“Successful Approaches for Controlling Genotoxins in APIs,” invited lecture at the AMRI Chemical Development Symposium, Albany NY, Aug. 26, 2009.

“Demystifying Process Chemistry,” Pre-Conference Workshop presented at Cambridge Healthtech Institute’s Mastering Process Chemistry Symposium, Philadelphia PA, November 17, 2008, and October 15, 2007.

Invited lectures at Oregon State University, as part of the Industrial Chemistry course, April 7 – 11, 2008.

“Process Validation from the Standpoint of an Organic Chemist,” invited lecture at the AMRI Chemical Development Symposium, Albany NY, Sept. 28, 2007 and Cambridge Healthtech Institute’s Mastering Process Chemistry Symposium, Philadelphia PA, Oct. 16, 2007.

“Developing Crystallization-Induced Stereoselective Processes,” invited lecture at the AMRI Chemical Development Symposium, Albany NY, May 5, 2005.

“Process R&D – How Much, How Soon?” invited lectures at the Siegfried Symposium on Successful Drug Development in the Biotech Industry, San Diego, CA, April 3-4, 2003, and at the AMRI Chemical Development Symposium, Albany NY, May 8, 2003.

“First Principles of Process Development” and “Application of Process Principles for Successful Scale-Up,” invited lectures at the ACS ProSpectives Symposium on Process Chemistry in the Pharmaceutical Industry, San Juan, Puerto Rico, February 2-5, 2003.

Invited lectures at Queens College (September 22, 1999), Lehigh University (July 27, 1999), UC / Santa Barbara and UC / Riverside (February 1995), and SUNY / Binghamton (November 6, 1985).

In-house and public courses presented internationally on process research & scale-up since 1998, some through the American Chemical Society.