Processing may be easier with reduced cost of goods if that catalyst is not needed. For instance, with the introduction of each additional component come not only increased costs to purchase and qualify the material, but also an increased burden of removing the component and possibly analyzing for the impurity in the product. Of course increased reaction rates and improved impurity profiles with a catalyst can readily compensate for these increased costs. Screening may demonstrate that a catalyst is actually detrimental (for an example of adding a thiol to an epoxide, see Schwartz, A.; Madan, P. B.; Mohacsi, E.; O’Brien, J. P.; Todaro, L. J.; Coffen, D. L. J. Org. Chem. 1992, 57, 851).
-
About
-
NEAL G. ANDERSON, Ph.D.
ANDERSON'S PROCESS SOLUTIONSMcMinnville, Oregon 97128
(541)778-0516
-
- SCHEDULE A SHORT COURSE IN-HOUSE
Customize For Your Company
In-house short courses allow researchers to identify and focus on skills and challenges unique to your company. In-house courses also provide a considerable savings in both registration fees and time away from the work site.
More Information on SHORT COURSES HERE
-
PROCESS TIPS
- Could NDMA be present in process water?
- Smelly Impurities
- Metathesis catalysts and reducing olefin isomerization
- Removing Ru from metathesis reactions
- Benzene as contaminant
- Removing Metal Ions from Reactors
- Recent review on statistical DoE
- How Much? 2-Ethylhexanoic Acid Limits
- Quenching carbodiimides
- Highlighting Continuous Flow Chemistry
- Controlling Residual Arylboronic Acids as Potential Genotoxic Impurities in APIs
- Recent Process Validation Guidance and Process Implementation
- A Perspective on Biocatalysis
- Roles of Water in Metal-Catalyzed Cross-Couplings
- Functional Group Conversions by Biocatalysts
- Expanding Potential for Biocatalysis
- Addition Sequence for Solvents and Solids Can Be Important
- Is a Catalyst Really Necessary?
- Screen Crystallization Solvents with H2O Present
- Designing Routes and Selecting Reagents
- NAVIGATION
- Bookmarks
- Tags