When designing routes and selecting reagents, carefully consider the toxicity and safe handling of reagents. Incorporating a potentially genotoxic intermediate into a route may be necessary to reduce the preparation time and cost of goods, thus outweighing the costs of handling and removing this intermediate from the product. On the other hand, if pilot plant personnel are unwilling to sample a drum of a dangerous reagent prior to using this lot in pilot plant scale-up, this raw material should be avoided: use-tests of individual lots are essential before committing valuable time and materials to scale-up. Consult with others on the toxicity and safe handling of reagents.
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NEAL G. ANDERSON, Ph.D.
ANDERSON'S PROCESS SOLUTIONSMcMinnville, Oregon 97128
(541)778-0516
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PROCESS TIPS
- Could NDMA be present in process water?
- Smelly Impurities
- Metathesis catalysts and reducing olefin isomerization
- Removing Ru from metathesis reactions
- Benzene as contaminant
- Removing Metal Ions from Reactors
- Recent review on statistical DoE
- How Much? 2-Ethylhexanoic Acid Limits
- Quenching carbodiimides
- Highlighting Continuous Flow Chemistry
- Controlling Residual Arylboronic Acids as Potential Genotoxic Impurities in APIs
- Recent Process Validation Guidance and Process Implementation
- A Perspective on Biocatalysis
- Roles of Water in Metal-Catalyzed Cross-Couplings
- Functional Group Conversions by Biocatalysts
- Expanding Potential for Biocatalysis
- Addition Sequence for Solvents and Solids Can Be Important
- Is a Catalyst Really Necessary?
- Screen Crystallization Solvents with H2O Present
- Designing Routes and Selecting Reagents
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