ADVANCED TOPICS CAN BE PRESENTED IN THE FOLLOWING AREAS
One-half day (8:30—noon): two topics
Green chemistry considerations
PMI to determine “greenness” of processes
Good route design lowers the cost of goods
Principles behind green chemistry success stories
Continuous processing
For safety, yield, quality, economics
When continuous operations makes sense
Selecting reactors: microreactors, PFRs, CSTRs, static mixers, STTs
Continuous reactions, separations, & crystallizations
One-half day (1:30—5:00): two topics
Crystallization and final form
Principles for effective crystallization
Polymorphs, monotropic & enantiotropic
Controlling PSD without milling
Considering alternative formulations
Genotoxic impurities
Functional groups flagged for PGIs
ACE: Avoid, Control, Expel
Alternative strategies
Quality by design (QbD) & case studies
