When designing routes and selecting reagents, carefully consider the toxicity and safe handling of reagents. Incorporating a potentially genotoxic intermediate into a route may be necessary to reduce the preparation time and cost of goods, thus outweighing the costs of handling and removing this intermediate from the product. On the other hand, if pilot plant personnel are unwilling to sample a drum of a dangerous reagent prior to using this lot in pilot plant scale-up, this raw material should be avoided: use-tests of individual lots are essential before committing valuable time and materials to scale-up. Consult with others on the toxicity and safe handling of reagents.
- NEXT TWO-DAY PUBLIC SHORT COURSE
PRACTICAL PROCESS RESEARCH & SCALE-UP
September 18-19, 2013
Princeton, New Jersey
Each course is updated prior to presentation.
NEAL G. ANDERSON, Ph.D.
ANDERSON'S PROCESS SOLUTIONS
Jacksonville, Oregon 97530
- Process Tips
- Tagsaddition sequence arylboronic acid biocatalysis biocatalyst biocatalytic biotransformation boronic acid boroxine catalyst cesium carbonate Codexis cost of goods cross-coupling deboronation enzymes green chemistry H2O hydrolysis KRED lipase manufacturing Merck oxidation palladium PAT polymorph formation potential genotoxic impurity process analytical technology process chemistry process implementation processing process validation reagents routes route scouting screen crystallization sitagliptin solvents SPC static discharge statistical process control Suzuki-Miyaura reaction transaminase use-test water