Screen crystallization solvents for H2O, as a small amount of H2O in solvents or reagents can affect not only the formation of hydrates but also polymorph formation. For an example of how small amounts of water in a starting material affected polymorph formation, see Gross, T. D.; Schaab, K.; Ouellette, M.; Zook, S.; Reddy, J. P.; Shurtleff, A.; Sacaan, A. I.; Alebic-Kolbah, T.; Bozigian, H. Org. Process Res. Dev. 2007, 11, 365.
- NEXT TWO-DAY PUBLIC SHORT COURSE
PRACTICAL PROCESS RESEARCH & SCALE-UP
September 18-19, 2013
Princeton, New Jersey
Each course is updated prior to presentation.
NEAL G. ANDERSON, Ph.D.
ANDERSON'S PROCESS SOLUTIONS
Jacksonville, Oregon 97530
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- Tagsaddition sequence arylboronic acid biocatalysis biocatalyst biocatalytic biotransformation boronic acid boroxine catalyst cesium carbonate Codexis cost of goods cross-coupling deboronation enzymes green chemistry H2O hydrolysis KRED lipase manufacturing Merck oxidation palladium PAT polymorph formation potential genotoxic impurity process analytical technology process chemistry process implementation processing process validation reagents routes route scouting screen crystallization sitagliptin solvents SPC static discharge statistical process control Suzuki-Miyaura reaction transaminase use-test water