Screen Crystallization Solvents with H2O Present

March 18th, 2010 Leave a reply »

Screen crystallization solvents for H2O, as a small amount of H2O in solvents or reagents can affect not only the formation of hydrates but also polymorph formation.   For an example of how small amounts of water in a starting material affected polymorph formation, see Gross, T. D.; Schaab, K.; Ouellette, M.; Zook, S.; Reddy, J. P.; Shurtleff, A.; Sacaan, A. I.; Alebic-Kolbah, T.; Bozigian, H. Org. Process Res. Dev. 2007, 11, 365.

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