Advanced Topics

ADVANCED TOPICS CAN BE PRESENTED IN THE FOLLOWING AREAS

One-half day (8:30—noon): two topics

Green chemistry considerations

PMI to determine “greenness” of processes

Good route design lowers the cost of goods

Principles behind green chemistry success stories

Continuous processing

For safety, yield, quality, economics

When continuous operations makes sense

Selecting reactors: microreactors, PFRs, CSTRs, static mixers, STTs

Continuous reactions, separations, & crystallizations

One-half day (1:30—5:00): two topics

Crystallization and final form

Principles for effective crystallization

Polymorphs, monotropic & enantiotropic

Controlling PSD without milling

Considering alternative formulations

Genotoxic impurities

Functional groups flagged for PGIs

ACE: Avoid, Control, Expel

Alternative strategies

Quality by design (QbD) & case studies

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